Niacin Alternatives for Dyslipidemia: Fool’s Gold or Gold Mine? Part I: Alternative Niacin Regimens
نویسندگان
چکیده
منابع مشابه
Niacin Alternatives for Dyslipidemia: Fool’s Gold or Gold Mine? Part I: Alternative Niacin Regimens
Niacin was the first drug demonstrating lowered cholesterol prevents coronary heart disease (CHD) events, with two clinical CHD outcome studies establishing a cardioprotective niacin regimen: 1 g thrice daily with meals. Though cardioprotective, skin toxicity limits niacin's use, fostering several variations to improve tolerability. One of these, an extended-release (ER) alternative, proved imm...
متن کاملNiacin Alternatives for Dyslipidemia: Fool’s Gold or Gold Mine? Part II: Novel Niacin Mimetics
Two cardiovascular outcome trials established niacin 3 g daily prevents hard cardiac events. However, as detailed in part I of this series, an extended-release (ER) alternative at only 2 g nightly demonstrated no comparable benefits in two outcome trials, implying the alternative is not equivalent to the established cardioprotective regimen. Since statins leave a significant treatment gap, this...
متن کاملInositol Hexaniacinate: A Safer Alternative to Niacin
Niacin has long been prescribed for the treatment of various cardiovascular conditions, particularly the hyperlipidemias. It has been proven effective at lowering VLDL, LDL, total cholesterol and triglyceride levels while raising HDL levels. The side effects of niacin which may occur at the dosages often required for therapeutic efficacy, ranging from flushing and pruritus to hepatoxicity and i...
متن کاملLast Words: Amazon Mechanical Turk: Gold Mine or Coal Mine?
Recently heard at a tutorial in our field: “It cost me less than one hundred bucks to annotate this using Amazon Mechanical Turk!” Assertions like this are increasingly common, but we believe they should not be stated so proudly; they ignore the ethical consequences of using MTurk (Amazon Mechanical Turk) as a source of labor. Manually annotating corpora or manually developing any other linguis...
متن کاملAmazon Mechanical Turk: Gold Mine or Coal Mine?
Recently heard at a tutorial in our field: “It cost me less than one hundred bucks to annotate this using Amazon Mechanical Turk!” Assertions like this are increasingly common, but we believe they should not be stated so proudly; they ignore the ethical consequences of using MTurk (Amazon Mechanical Turk) as a source of labor. Manually annotating corpora or manually developing any other linguis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Atherosclerosis Reports
سال: 2016
ISSN: 1523-3804,1534-6242
DOI: 10.1007/s11883-016-0563-8